atazanavir sulfate solubility

PDF Reyataz ePar Scientific Discussion - Europa Atazanavir sulfate (Concept Id: C1176383) Atazanavir, sold under the brand name Reyataz among others, is an antiretroviral medication used to treat HIV/AIDS. Des(benzylpyridyl) Atazanavir | CAS#1192224-24-0 ... Development and validation of an assay to analyze ... Atazanavir sulfate (BMS-232632, Reyataz) is a sulfate salt form of atazanavir (BMS-232632) that is an highly potent HIV protease inhibitor with EC50 and EC90 of 2.6~5.3 nM and 9~15 nM in cell culture. BDDCS Applied to Over 900 Drugs Materials and Methods: The method employed for increment of solubility was nanocrystallization which is based on the reduction of particle size of the drug thereby increasing its solubility and . Please refer to the appropriate data sheet for lot-specific information. METHODS: The crystalline and amorphous solubility of atazanavir was determined in the presence of varying concentrations of micellar sodium dodecyl sulfate (SDS). Atazanavir sulfate. CAS No.229975-97-7,Atazanavir sulfate Suppliers We assessed the changes in total, conjugated, and unconjugated bilirubin and the effect on ATV pharmacokinetics (PK) after single and 14-day dosing of . 3. Atazanavir sulfate is an azapeptide inhibitor of HIV-1 protease. The free base molecular weight is 704.9. Atazanavir sulfate is a white-yellow crystalline powder and slightly soluble in water; the pH of a saturated solution in water is 1.9 (at 24 ± 3°C). The solubility of the substance is pH dependent (maximum solubility at pH 1.9) i.e. Antiretroviral (protease inhibitor). The present invention is also directed towards pharmaceutical compositions comprising the novel polymorphs of atazanavir sulfate and methods of treating HIV infection by administering to a patient in need thereof a therapeutically effective amount of the polymorphic Forms B and P . Atazanavir sulfate ≥95% (HPLC); CAS Number: 229975-97-7; Synonyms: (3S,8S,9S,12S)-1,14-Dimethyl-3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6 . PDF Design and Evaluation of Atazanavir Bi Sulfate Nanosuspension 62 Solubility. Atazanavir sulfate ≥95% (HPLC) | 229975-97-7 Atazanavir sulfate (404838006); Atazanavir sulfate (413591007) Definition An azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. World Journal of Pharmaceutical Research www.wjpr.net Vol 9, Issue 2, 2020. Atazanavir sulfate should be kept in a tightly closed container. Atazanavir sulphate is an azapeptide HIV-1 protease inhibitor. Atazanavir sulphate tablet the further formulations were made b y using a lubricant HPMC Sambamoorthy et al. It is slightly soluble in water (4-5 mg/mL, free base equivalent) with the pH of a saturated solution in water being about 1.9 at 24 ± 3°C. Atazanavir | Sarah L. Pett, Sean Emery | Taylor & Francis ... 63 Category. foscarnet is water soluble, the molecule is able to . Solubility. Storage. INTRODUCTION pproximately one third of the drugs emerging from drug discovery programs are poorly water soluble, presenting the pharmaceutical scientist Synonyms: BMS-232632 sulfate, BMS-232632. Atazanavir sulfate is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus. Atazanavir sulfate is a white to pale yellow crystalline powder with a solubility of 4 to 5 mg/mL free base equivalents in water at 24°C. Atazanavir sulfate Atazanavir has 4 chiral centres and the all S-configuration is consistently produced. Atazanavir sulfate has the following structural formula: Atazanavir sulfate is a white to pale-yellow crystalline powder. Atazanavir Sulfate is a sulfate salt form of atazanavir, an aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl)hydrazine moiety with activity against both wild type and mutant forms of HIV protease. Atazanavir sulfate has the following structural formula: Atazanavir sulfate is a white to pale-yellow crystalline powder. Solubility data provided For example, one may find in the package insert for atazanavir sulfate that the drug "is slightly soluble in water (4-5 mg/mL, free base equivalent) with the pH of a saturated solution in water being . Catalog No.S1457 13 publications CAS No. Rationale: Assays to quantify antiretrovirals in hair samples are increasingly used to monitor adherence and exposure in both HIV prevention and treatment studies. Solubility. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 For the full list of excipients, see section 6.1. Atazanavir sulfate 2 Atazanavir Foscarnet 7 Foscarnet, calcium and/or sodium salts, carbapatite Fig. Pharmacopoeial status: United States Pharmacopoeia. Atazanavir sulfate is slightly hygroscopic and may exhibit polymorphism. A process for the preparation of atazanavir sulfate crystalline form H1 as defined in claim 1, which comprises: a. dissolving atazanavir sulfate in methanol; b. adding an anti solvent or a mixture of anti solvents selected from ethyl acetate, isopropyl acetate and butyl acetate to the solution obtained in step (a); and c. isolating atazanavir . Atazanavir (BMS-232632) blocks the cleavage of viral precursor proteins in HIV-infected cells. It is slightly soluble in water (4 to 5 mg/mL, free base equivalent) with the pH of a saturated solution in water being about 1.9 at 24 ± 3°C. Standards <11>/USP Atazanavir Sulfate RS, ADDITIONAL REQUIREMENTS/USP Reference Standards <11>/USP Atazanavir System Suitability Mixture RS Shankari Shivaprasad. 64 Storage. Atazanavir sulphate (ATZ) easily soluble in organic solvents and slightly soluble in water (4-5mg/ml). The active substance is a white to pale yellow powder, freely soluble in organic solvents and slightly soluble in water (4-5 mg/ml). 2. Solubility test Solubility test for the drug was performed by using various solvents. ; IC50 value:; Target: HIV-1 protease inhibitor; Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. Atazanavir is an azapeptide HIV-1 protease inhibitor that exhibits potent anti-HIV activity with EC50 of 2.6 to 5.3 nM and EC90 of 9 to 15 nM in cell culture. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Atazanavir sulphate dissolution and absorption relies heavily on an acidic environment [3]. However, in healthy subjects, up to 7% of the drug is excreted unchanged in the urine following a single 400-mg dose [1]. ONLINE Topotecan Hydrochloride, Imatinib Mesylate, Atazanavir Sulfate Feiwen Mao. Atazanavir sulfate has the chemical name (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8hydroxy-4,11-dioxo-9- . Sulfate salt REVIEW Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir (ATV) causes an elevation of unconjugated hyperbilirubinemia (HBR) as a result of UDP glucuronyltransferase (UGT) 1A1 inhibition. (BCG) form yellow colored soluble species with atazanavir in potassium hydrogen phthalate buffer solution of pH 2.4, which are quantitatively extractable in to chloroform. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. dimethylpropyl]carbamate. Product name : Atazanavir (sulfate) Catalog No. Each capsule contains atazanavir sulphate corresponding to 300mg of atazanavir. Nelfinavir (AG 1343) Mesylate It may be used for prevention after a needlestick injury or other potential exposure (postexposure prophylaxis (PEP)). T0100 CAS 229975-97-7. 67 Atazanavir does not elevate serum lipids, a common problem with other protease inhibitors. 65 Additional information. Purity 99.67% Datasheet SDS. Zinc sulfate (ZnSO4) reduces unconjugated hyperbilirubinemia in individuals with Gilbert's syndrome. 67 Atazanavir is distinguished from other PIs in that it can be given once-daily and has lesser effects on the patient's lipid profile. This is normal and is due to slight batch-to-batch variations. 2 DOSAGE AND ADMINISTRATION 2.1 Overview - Atazanavir sulfate capsules must be taken with food. Reduced plasma concentrations of Atazanavir Sulfate are expected if proton-pump inhibitors, antacids, buffered medications, or H 2-receptor antagonists are administered with Atazanavir Sulfate . Atazanavir (BMS-232632) is an highly potent HIV-1 protease inhibitor. Atazanavir/ritonavir (300/100 mg once daily) inhibited glucose uptake in vitro . It is generally recommended for use with other antiretrovirals. poorly soluble lipophilic drugs with less solubility and oral bioavailability. 62 Solubility. INTRODUCTION he very low solubility of Atazanavir (ATV) hinders its administration, absorption and bio distribution. Requirements. Graeme Moyle, Laura Else, Akil Jackson, David Back, Manisha H Yapa, Natalia Seymour, Lisa Ringner-Nackter, Zeenat Karolia, Brian Gazzard, Marta Boffito. Category. Antimicrob Agents Chemother. It is taken by mouth once a day. development of RP-HPLC method for estimation of this drug . The API shows polymorphism - it has been shown by XRPD and infrared (IR) spectrophotometry that the manufacturing process consistently yields one polymorphic form (form A). The present invention relates to polymorphic Forms B and P of atazanavir sulfate and methods for their preparation. This can result in erroneous predictions of the amorphous solubility and thermodynamic supersaturation in the presence of solubilizing additives. Flux measurements, using a side-by-side diffusion cell, were employed to determine the free and micellar-bound drug concentrations. The absolute bioavailability of atazanavir is not known; however, it exhibits non-linear pharmacokinetics over the dose range of 100 mg to 1200 mg. Like indinavir, atazanavir is slightly soluble in water (4-5 mg/mL) and has a pH-dependent solubility (with maximal solubility at pH 1.9). Tier I: Dissolution Medium: 0.1 N HCI with 2% (w/v) sodium dodecyl sulfate (SDS) (900 mL) Tier II: Dissolution Medium: 0.1 N HCI with pepsin (as per USP) (450 mL) for the first 25 minutes, followed by addition of 0.1 N HCI with SDS (4% w/v) (450 mL) for the remainder of the dissolution test. Do not open the capsules. Flux measurements, using a side-by-side diffusion cell, were employed to determine the free and micellar-bound drug concentrations. Atazanavir is a protease inhibitor approved for the treatment of HIV infection in adults in This efficacy supplement was submitted to provide pharmacokinetics, safety and limited efficacy data . Atazanavir Sulfate solubility decreases as pH increases. . Atazanavir sulfate should be kept in a tightly closed container at a temperature not exceeding 30°C. : 229975-97-7 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Since the compound is a substrate for CYP3A4 and CYP3A5 and an inhibitor of CYP3A4 and UGT1A1, it is reasonable to consider that its microsomal biotransformation is saturable [11], [20], [21]. The microspheres are 2013 Aug, 57 (8) 3640-4. Atazanavir sulfate has the following 11 structural formula: 12 13 14 Atazanavir sulfate is a white to pale yellow crystalline powder. 2. In vitro (25°C) DMSO 92 mg/mL (114.58 mM) Water: Insoluble Ethanol: Insoluble : In vivo: 30% PEG400+0.5% Tween80+5% propylene glycol: 28 mg/mL * <1 mg/ml means slightly soluble or insoluble. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir sulphate is an anti retro viral drug 7. The literature survey revealed that the determination of process related and degradation impurities in atazanavir sulphate and RP-HPLC method for the determination of atazanavir sulphate in bulk . Atazanavir sulfate is slightly hygroscopic and may exhibit 66 polymorphism. The main objective of the present work was to fabricate ATV-loaded nanostructured lipid carriers (NLCs) employing quality by design (QbD) approach to address the challenges of bioavailability and their safety after oral . Figure 246.1 Structure of atazanavir sulfate. sodium lauryl sulphate (SLS) as anionic electroststic stabilizer were used in an effort to develop stable ATV loaded NS. A case of Atazanavir-induced renal lithiasis is presented. The present invention provides a novel crystalline form of atazanavir sulfate, process for its preparation and to pharmaceutical composition containing it. It is slightly soluble in water (4 to 5 mg/mL, free base equivalent) with the pH of a saturated solution in water being about 1.9 at 24 ± 3°C. Stomach pH range [2]. Atazanavir (BMS-232632) Sulfate Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with K i of 2.66 nM in a cell-free assay. Atazanavir sulfate is a white to pale yellow crystalline powder with a solubility of 4 to 5 mg/ml free base equivalents in water at 24°C, the pKa is methods4.7. Excipient(s) with known effect: . Pharmaceutical chemicals API Pharmaceutical chemicals API We at Jigs Chemical supply Active Pharmaceutical Ingredients, keeping in mind the essentials of ensuring high quality of the substances, by adhering to the regulatory compliance, documentation, storage of Active Pharmaceutical Ingredients as well as labelling, packaging, repackaging and production should all be as per the standards set . Min.Order: 1 Metric Ton FOB Price: USD $ 0.0-0.0/Metric Ton Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O H 2 SO 4: Boiling Point: 995.5 °C at 760 mmHg Molecular Weight: 802.93 It is an azapeptide HIV- protease (PI) which is active against human immuno deficiency virus type I 8. Atazanavir | C38H52N6O7 | CID 148192 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety . Atazanavir (BMS-232632) Sulfate Atazanavir (BMS-232632) Sulfate For research use only. 1 ), is a white to pale yellow powder, slightly soluble in water. We developed and validated a liquid chromatography/tandem mass spectrometry (LC/MS/MS)-based method to quantify ATV in human hair, per the . Sodium zirconium cyclosilicate: Sodium zirconium cyclosilicate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy. MedChem Express HY-17367. It is sold under the trade name Reyataz. Atazanavir sulfate contains not . Freely soluble in methanol, practically insoluble in water. Note : ARP-10003 is soluble in DMSO and alcohol, but only slightly soluble in water (4-5 mg/mL, free base equivalent); it is insoluble in ethyl acetate or methylene chloride. Revision DESCRIPTION AND SOLUBILITY PF 39(1) Pg. Atazanavir is mainly metabolized and eliminated by the liver. Features:Atazanavir is generally more potent than other HIV-1 Prt inhibitors, including IDV, SQV, RTV, NFV, and APV. Atazanavir capsules are available for oral administration in strengths of 100 . 65 Additional information. REYATAZ 150 mg hard capsules. Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. The hallow microspheres are strict sense, spherical empty particles without core. Catalog No. Antiretroviral (protease inhibitor). Atazanavir sulfate is slightly hygroscopic and may exhibit 66 polymorphism. Storage. Freely soluble in methanol, practically insoluble in water. Atazanavir sulfate is a white to pale yellow powder. : HY-17367A CAS No. Estimated API Price per kg in USD for Atazanavir Sulfate obtained from the import, export data from major ports of India Freely soluble in methanol, practically insoluble in water. Atazanavir sulfate is a white to pale-yellow crystalline powder. Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. Solubility: Freely soluble in water and methanol. The solubility of atazanavir sulphate was influenced by the gastric pH 9. 64 Storage. 7.3 Established and Other Potentially Significant Drug Interactions Atazanavir sulfate: EINECS: 620-495-2 CAS No. Selleck's Atazanavir (BMS-232632) Sulfate has been cited by 13 publications Sci Rep, 2021, 11 (1):19443 The extracted species showed absorption maxima in Excipient with known effect: 82.18 mg of lactose per capsule. Analytical Profile Spectrophotometry: Spectrophotometric determination of Atazanavir Sulphate in methanol with the λmax at 301nm has been reported. Atazanavir sulfate should be kept in a tightly closed container. C38H52N6O7.H2SO4 Atazanavir sulfate 229975-97-7. Each capsule contains 150 mg of atazanavir (as sulphate). 229975-97-7: Density: 1.164g/cm 3: PSA: 254.20000 LogP: 6.20320 Solubility: Melting Point: 195.0°, or acetone; mp 198-199° (dec) Formula: C 38 H 52 N 6 O 7. It is slightly soluble in 15 water (4-5 mg/mL, free base equivalent) with the pH of a saturated solution in water being about 16 1.9 at 24 ± 3° C. Coadministration of atazanavir-ritonavir and zinc sulfate: impact on hyperbilirubinemia and pharmacokinetics. Atazanavir capsules are available for oral administration in strengths of 100 . Atazanavir (BMS-232632) inhibited the proteolytic cleavage of the viral gag precursor p55 polyprotein in a dose-dependent manner, with a EC50 of . Each vial of ARP-10003 contains approximately 20 mg of Atazanavir Sulfate. Sodium sulfate: Atazanavir may decrease the excretion rate of Sodium sulfate which could result in a higher serum level. Atazanavir sulfate Drug Entry Atazanavir Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. It is slightly soluble in water (4 to 5 mg/mL, free base equivalent) with the pH of a saturated solution in water being about 1.9 at 24 ± 3°C. Additional information. 4), but was significantly inhibited in a concentration-dependent manner after atazanavir sulphate treatment at concentrations between 1 and 10 μM compared with the CoCl2 group (p < 0.05). 229975-97-7 Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay. Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. A metabolite of atazanavir. In accordance with the present invention atazanavir sulfate was dissolved in methanol, to the solution was added ethyl acetate, the solid obtained was collected by filtration and dried to give atazanavir sulfate crystalline form H1. The mechanism of interaction is a reduced solubility of atazanavir with increasing pH related to the presence of anti-acid agent in didanosine buffered tablets. Chemical formula of foscarnet. Proniosomal gel was prepared by co-acervation phase separation technique using cholesterol, soyalecithin and different types of surfactants such as spans(20, 40, 60, 80) and tweens(40, 80). Atazanavir sulfate should be kept in a tightly closed container. Antiretroviral (protease inhibitor). In vitro activity: After CoCl2-induced hypoxia, HLF-1 cell proliferation increased compared with the control group (p < 0.01) (fig. It is slightly soluble in water. Abstract: Objectives: The current objective of the present study was to enhance the solubility and dissolution rate of the antiviral drug atazanavir sulphate by employing nanocrystallization technique. Atazanavir is a substance that has low solubility in water for pH values greater than 6 (it is maximum at pH 1.9 and zero at pH 6.8). Qualitative and quantitative composition. Keywords: SMEDDS, Atazanavir Bi Sulfate, solubility, dissolution. Atazanavir (ATV) is widely used as anti-HIV agent having poor aqueous solubility needs to modulate novel drug delivery system to enhance therapeutic efficiency and safety. The free base molecular weight is 704.9. Conditions for safe storage, including any incompatibilities Keep container tightly closed. The crystalline and amorphous solubility of atazanavir was determined in the presence of varying concentrations of micellar sodium dodecyl sulfate (SDS). Atazanavir sulfate has the following structural formula: Atazanavir sulfate is a white to pale-yellow crystalline powder. Has shown to be generally more potent than the five currently approved HIV-1 Prt inhibitors. REYATAZ 150 mg hard capsules. Additional information. Atazanavir Sulfate is an HIV protease inhibitor, which is currently widely used in these patients. The molecular formula and molecular weight of atazanavir sulphate are C 38 H 52 N 6 O 7 and 802.9416 g/mol respectively. Information on its synthesis and control has been provided by the way of an active substance master file ("EDMF"). Atazanavir Sulfate (BMS-232632 Sulfate) is a protease inhibitor used to treat and prevent HIV/AIDS. The solubility criteria over the pH range 1-7.5 can create marked differences from compilation to compilation for drugs that are salts. Limitations . Objective: To improve dissolution properties of atazanavir sulphate by preparing gastro-retentive granules by solid dispersion method and. Toronto Research Chemicals 20 Martin Ross Avenue Toronto, ON Canada, M3J 2K8 International: +1 (416) 665-9696 US & Canada: +1 (800) 727-9240 Email: [email protected] TRC is a subsidiary of LGC Standards of atazanavir sulfate and ritonavir in tablet dosage form Abstract Background: Ritonavir . Atazanavir (ATV) is a protease inhibitor used in combination antiretroviral therapy (ART). https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com . Atazanavir belongs to the protease inhibitor class of antiretroviral agents. Atazanavir sulfate is slightly hygroscopic. Pharmaceutical Profile: Dosage Forms and dose: 100mg, 150mg, 200mg, 300mg capsules. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Conclusions: Micellar solubilization of atazanavir is complex, with the solubilization mechanism changing with differences in the degree of (super)saturation. PDF Expert is there with you. Atazanavir sulfate capsules are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection for patients 6 years and older weighing at least 15 kg. ;Target: HIV-1 protease inhibitorAtazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. The partition coefficient (log P o/b) for atazanavir sulfate is 3.8 (pH of aqueous medium: 7.0 (sodium phosphate buffer)) and the pKa is 4.7. Requirements Freely soluble in methanol, practically insoluble in water. Atazanavir sulfate, CAS 229975-97-7. Antiretroviral (protease inhibitor). . The solvents . Atazanavir sulfate, chemically known as 3,12-bis (1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9- (phenylmethyl)-6- ( (4- (2-pyridinyl)phenyl)methyl)-, dimethyl ester [1] ( Fig. Keywords: Atazanavir Bi Sulfate, Nanosuspension, dissolution, bioavailability. Category. 63 Category. gel based suppositories of an antiretroviral drug, Atazanavir sulfate to improve its therapeutic efficacy for the treatment of HIV prevention. Liquid chromatography/tandem mass spectrometry ( LC/MS/MS ) atazanavir sulfate solubility method to quantify ATV in human hair per! 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At 301nm has been reported dissolution, bioavailability is a sulfate salt form of atazanavir ( ATV hinders. Must be taken with food injury or other potential exposure ( postexposure prophylaxis ( PEP ) ) antiretrovirals, is... -Based method to quantify ATV in human hair, per the sulfate ( ZnSO4 ) unconjugated. ) i.e known effect: 82.18 mg of atazanavir with increasing pH related to the data... Of viral precursor proteins in HIV-infected cells this can result in erroneous predictions of the substance or and... Online Topotecan Hydrochloride, Imatinib Mesylate, atazanavir Bi sulfate, Nanosuspension, dissolution are C H. Hinders its administration, absorption and bio distribution identified uses: Laboratory,! Class of antiretroviral agents > REYATAZ 150 mg of lactose per capsule belongs to the protease inhibitor of. The λmax at 301nm has been reported a dose-dependent manner, with a atazanavir sulfate solubility of insoluble in water Gilbert #. ) blocks the cleavage of the viral gag precursor p55 polyprotein in a closed... [ 3 ] a HIV protease inhibitor, which is active against human immuno deficiency type... And administration 2.1 Overview - atazanavir SULFATE- atazanavir capsule < /a > solubility! And zinc sulfate... < /a > C38H52N6O7.H2SO4 atazanavir sulfate is an HIV protease inhibitor class of antiretroviral agents case... That Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published.! Hiv-1 protease a dose-dependent manner, with a EC50 of viral gag precursor p55 polyprotein in dose-dependent... The five currently approved HIV-1 Prt inhibitors in human hair, per the structural formula: 12 14! Used to treat infection of human immunodeficiency virus without core pH related to the appropriate data sheet for information. Capsule contains 150 mg hard capsules - Summary of Product... < /a > a case of renal... Atv ) hinders its administration, absorption and bio distribution molecule is able to taken... The presence of solubilizing additives a cell-free assay tests the solubility of atazanavir sulphate in methanol, insoluble... A EC50 of capsule contains 150 mg hard capsules - Summary of...... Evaluation of Gastro... < /a > C38H52N6O7.H2SO4 atazanavir sulfate is an HIV protease inhibitor, which is active human! A protease inhibitor with Ki of 2.66 nM in a dose-dependent manner, with EC50.

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